Direct Michael addition/decarboxylation reaction catalyzed by a composite of copper ferrite nanoparticles immobilized on microcrystalline cellulose: an eco-friendly approach for constructing 3,4-dihydrocoumarin frameworks

Bhupender Kumar; Biplob Borah; J Nagendra Babu; L Raju Chowhan

doi:10.1039/d2ra05994k

Direct Michael addition/decarboxylation reaction catalyzed by a composite of copper ferrite nanoparticles immobilized on microcrystalline cellulose: an eco-friendly approach for constructing 3,4-dihydrocoumarin frameworks

RSC Adv. 2022 Oct 27;12(47):30704-30711. doi: 10.1039/d2ra05994k. eCollection 2022 Oct 24.

Authors

Bhupender Kumar¹, Biplob Borah¹, J Nagendra Babu², L Raju Chowhan¹

Affiliations

¹ School of Applied Material Sciences, Central University of Gujarat, Sector 30 Gandhinagar Gujarat 382021 India rajuchowhan@gmail.com rchowhan@cug.ac.in.
² Department of Chemical Sciences, School for Basic and Applied Sciences, Central University of Punjab Ghudda Bathinda 151401 India.

Abstract

A composite of copper ferrite oxide nanoparticles immobilized on microcrystalline cellulose (CuFe₂O₄@MCC) was synthesized. The synthesized composite was characterized by FESEM with EDS-Mapping, TEM, P-XRD, TEM, and BET analysis and investigated for its catalytic activity toward Tandem Michael addition and decarboxylation of coumarin-3-carboxylic acid with cyclic 1,3-diketones to obtain novel 3,4-dihydrocoumarin derivatives. This protocol was established with wide substrate scope and significant yield. The significant characteristics of this methodology are mild reaction conditions, easy setup procedure, non-toxic, and cost-effectiveness. A gram-scale synthesis with low catalyst loading was also demonstrated.