Epigenetic-Mediated Regulation of Gene Expression for Biological Control and Cancer: Fidelity of Mechanisms Governing the Cell Cycle

Mohammed El Dika; Andrew J Fritz; Rabail H Toor; Princess D Rodriguez; Stephen J Foley; Rahim Ullah; Daijing Nie; Bodhisattwa Banerjee; Dorcas Lohese; Kirsten M Tracy; Karen C Glass; Seth Frietze; Prachi N Ghule; Jessica L Heath; Anthony N Imbalzano; Andre van Wijnen; Jonathan Gordon; Jane B Lian; Janet L Stein; Gary S Stein

doi:10.1007/978-3-031-06573-6_13

Epigenetic-Mediated Regulation of Gene Expression for Biological Control and Cancer: Fidelity of Mechanisms Governing the Cell Cycle

Results Probl Cell Differ. 2022:70:375-396. doi: 10.1007/978-3-031-06573-6_13.

Authors

Mohammed El Dika^#¹, Andrew J Fritz^#¹, Rabail H Toor¹, Princess D Rodriguez², Stephen J Foley¹, Rahim Ullah¹, Daijing Nie¹, Bodhisattwa Banerjee¹, Dorcas Lohese¹, Kirsten M Tracy¹, Karen C Glass³, Seth Frietze⁴, Prachi N Ghule¹, Jessica L Heath^{1

5}, Anthony N Imbalzano⁶, Andre van Wijnen¹, Jonathan Gordon¹, Jane B Lian¹, Janet L Stein¹, Gary S Stein⁷

Affiliations

¹ Department of Biochemistry, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA.
² Department of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, USA.
³ Department of Pharmacology, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA.
⁴ College of Nursing and Health Sciences, University of Vermont, Burlington, VT, USA.
⁵ Department of Pediatrics, Larner College of Medicine, University of Vermont, Burlington, VT, USA.
⁶ Department of Biochemistry and Molecular Biotechnology, UMass Chan Medical School, Worcester, MA, USA.
⁷ Department of Biochemistry, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA. gary.stein@med.uvm.edu.

^# Contributed equally.

Abstract

The cell cycle is governed by stringent epigenetic mechanisms that, in response to intrinsic and extrinsic regulatory cues, support fidelity of DNA replication and cell division. We will focus on (1) the complex and interdependent processes that are obligatory for control of proliferation and compromised in cancer, (2) epigenetic and topological domains that are associated with distinct phases of the cell cycle that may be altered in cancer initiation and progression, and (3) the requirement for mitotic bookmarking to maintain intranuclear localization of transcriptional regulatory machinery to reinforce cell identity throughout the cell cycle to prevent malignant transformation.

Keywords: Cell cycle control; Chromatin; Epigenetic control; Histones; Mitotic gene bookmarking; Nuclear structure; Nucleosomes; Transcription; Tumor suppression.

MeSH terms

Cell Cycle / genetics
Cell Division
Chromatin
Epigenesis, Genetic*
Gene Expression Regulation
Humans
Neoplasms* / genetics
Neoplasms* / pathology

Substances

Chromatin

Abstract

MeSH terms

Substances

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