The Hitchhiker's Guide across a Waddington's landscape of melanoma

Kerrie L Marie; Glenn Merlino; Chi-Ping Day

doi:10.1016/j.devcel.2022.10.005

The Hitchhiker's Guide across a Waddington's landscape of melanoma

Dev Cell. 2022 Nov 7;57(21):2447-2449. doi: 10.1016/j.devcel.2022.10.005.

Authors

Kerrie L Marie¹, Glenn Merlino², Chi-Ping Day³

Affiliations

¹ Division of Molecular and Cellular Function, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, M13 9PT. United Kingdom. Electronic address: kerrie.marie@manchester.ac.uk.
² Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20894, USA.
³ Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20894, USA. Electronic address: chi-ping.day@nih.gov.

PMID: 36347238
DOI: 10.1016/j.devcel.2022.10.005

Abstract

Melanoma evolution may recapitulate the embryonic development of its progenitor tissue, neural crest (NC), but the exact process is unclear. In a recent issue of Nature, Karras et al. (2022) demonstrate that melanoma expansion mirrors the hierarchic process of NC differentiation, generating cell subpopulations, each with distinct function, including growth and metastasis.

MeSH terms

Cell Differentiation
Humans
Melanoma*
Neural Crest
Organogenesis