The generation and regulation of chirality are closely related to the origin of life. Using achiral precursors to spontaneously build chiral MOFs remains a major challenge. Here, a method to synthesize chiral MOFs from achiral precursors by utilizing chiral fragments was achieved. The transformation from chiral fragments of 1 to chiral frameworks of 2 and 3 was realized by modifying the substituents, and the enantiomer resolution of 3-P41212 and 3-P43212 was achieved by d/l camphoric acid. 3 was then further studied in applications.