SPR Based Biosensing Chip for COVID-19 Diagnosis-A Review

Purnendu Shekhar Pandey; Sanjeev Kumar Raghuwanshi; Azhar Shadab; Md Tauseef Iqbal Ansari; Umesh Kumar Tiwari; Santosh Kumar

doi:10.1109/JSEN.2022.3181423

SPR Based Biosensing Chip for COVID-19 Diagnosis-A Review

IEEE Sens J. 2022 Jun 14;22(14):13800-13810. doi: 10.1109/JSEN.2022.3181423. eCollection 2022 Jul.

Authors

Purnendu Shekhar Pandey¹, Sanjeev Kumar Raghuwanshi², Azhar Shadab¹, Md Tauseef Iqbal Ansari¹, Umesh Kumar Tiwari³, Santosh Kumar⁴

Affiliations

¹ Optical Fiber Sensor LaboratoryDepartment of Electronics EngineeringIndian Institute of Technology (Indian School of Mines) Dhanbad Dhanbad Jharkhand 826004 India.
² Department of Electronics EngineeringIndian Institute of Technology (Indian School of Mines) Dhanbad Dhanbad Jharkhand 826004 India.
³ Advanced Materials and Sensors DivisionCentral Scientific Instruments Organisation (CSIO) Chandigarh 160030 India.
⁴ Shandong Key Laboratory of Optical Communication Science and Technology, School of Physics Science and Information TechnologyLiaocheng University Liaocheng 252059 China.

Abstract

Surface Plasmon Resonance (SPR) techniques are highly accurate in detecting biomolecular like blood group measurement, food adulteration, milk adulteration and recently developing as a rapid detection for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. In order to validate the clinical diagnosis, Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) of nasopharyngeal swabs has been utilized, which is time consuming and expensive. For fast and accurate detection of the SARS-CoV-2 virus, SPR based biosensing chips are described in this review article. SPR sensors have the potential to be employed for fast, accurate, and portable SARS-CoV-2 virus diagnosis. To combat the SARS-CoV-2 pandemic, there is considerable interest in creating innovative biosensors that are quick, reliable, and sensitive for COVID-19 diagnosis.

Keywords: 2-D materials; Kretschmann configuration; SARS-CoV-2; Surface plasmon resonance; biosensor.

Grants and funding

This work was supported by the Central Scientific Instruments Organisation (CSIR), Chandigarh, India, through the Project “Design and Development of Deployable Thin Film-Based Evanescent Field Sensor to Check the Quality of Food From Adulteration” under Sanction 70(0077)/19/EMR-II [CSIR(32)/2019-2020/663/ECE]. The work of Santosh Kumar was supported by the Double-Hundred Talent Plan of Shandong Province, China.