N-glycan branching enzymes involved in cancer, Alzheimer's disease and COPD and future perspectives

Naoyuki Taniguchi; Yuki Ohkawa; Kento Maeda; Noriko Kanto; Emma Lee Johnson; Yoichiro Harada

doi:10.1016/j.bbrc.2022.09.027

N-glycan branching enzymes involved in cancer, Alzheimer's disease and COPD and future perspectives

Biochem Biophys Res Commun. 2022 Dec 10:633:68-71. doi: 10.1016/j.bbrc.2022.09.027. Epub 2022 Sep 10.

Authors

Naoyuki Taniguchi¹, Yuki Ohkawa², Kento Maeda², Noriko Kanto², Emma Lee Johnson², Yoichiro Harada²

Affiliations

¹ Department of Glyco-Oncology and Medical Biochemistry, Research Center, Osaka International Cancer Institute, Osaka, Japan. Electronic address: glycotani@oici.jp.
² Department of Glyco-Oncology and Medical Biochemistry, Research Center, Osaka International Cancer Institute, Osaka, Japan.

PMID: 36344167
DOI: 10.1016/j.bbrc.2022.09.027

Abstract

Over the past 3 decades, our group has been involved in studies related to the biosynthesis of N-glycan branching and related glycosyltransferases and have purified most of these Golgi-derived enzymes to homogeneity using classical purification methods and cloned the cDNA of GnT-III, IV, V, VI and Fut8 except GnT-IX(Vb) which was obtained by homology cloning. Based primarily on our data, we briefly summarize the significance of three major enzymes and discuss perspectives for future studies on the occasion of Ernesto's 90th birthday celebration.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

1,4-alpha-Glucan Branching Enzyme*
Alzheimer Disease*
Humans
N-Acetylglucosaminyltransferases / genetics
Neoplasms*
Polysaccharides
Pulmonary Disease, Chronic Obstructive*

Substances

N-Acetylglucosaminyltransferases
1,4-alpha-Glucan Branching Enzyme
Polysaccharides