Programmed cell death: Past, present and future

Gelina S Kopeina; Boris Zhivotovsky

doi:10.1016/j.bbrc.2022.09.022

Programmed cell death: Past, present and future

Biochem Biophys Res Commun. 2022 Dec 10:633:55-58. doi: 10.1016/j.bbrc.2022.09.022.

Authors

Gelina S Kopeina¹, Boris Zhivotovsky²

Affiliations

¹ Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia.
² Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Electronic address: boris.zhivotovsky@ki.se.

PMID: 36344162
DOI: 10.1016/j.bbrc.2022.09.022

Abstract

It is known that all living organisms are mortal. For many decades, the main interest of researchers has been focused on the investigation of proliferation, differentiation and other fundamental cellular processes, completely ignoring the understanding of the mechanisms of cell elimination. Since the 60s-70s of the last century, a systematic study of cell death began, which is currently one of the most rapidly developing areas of biomedicine. Since this field of research is very wide, in these short notes we tried to discuss the hottest, but not all, topics that are of interest to many of our colleagues.

Keywords: Activated cell death; Development; Disease; Programmed cell death; Regulated cell death.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Apoptosis* / physiology
Cell Death
Cell Differentiation