Chronic Spontaneous Urticaria in Patients With Interstitial Cystitis/Bladder Pain Syndrome: Insights From Big Data Analyses

Omer Anis; Khalaf Kridin; Arnon Dov Cohen; Miriam Levmore; Shlomit Yaron; Yuliya Valdman-Grinshpoun; Tali Czarnowicki

doi:10.1016/j.urology.2022.10.017

Chronic Spontaneous Urticaria in Patients With Interstitial Cystitis/Bladder Pain Syndrome: Insights From Big Data Analyses

Urology. 2023 Jan:171:83-87. doi: 10.1016/j.urology.2022.10.017. Epub 2022 Nov 5.

Authors

Omer Anis¹, Khalaf Kridin², Arnon Dov Cohen³, Miriam Levmore⁴, Shlomit Yaron⁴, Yuliya Valdman-Grinshpoun⁵, Tali Czarnowicki⁶

Affiliations

¹ Urology department, Sheba Medical Center, Ramat Gan, Israel; The Mina & Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
² Unit of Dermatology and Skin Research Laboratory, Baruch Padeh Medical Center, Poriya, Tiberias, Israel; Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel; Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.
³ Department of Quality Measures and Research, Chief Physician's Office, Clalit Health Services, Tel Aviv, Israel; Siaal Research Center for Family Medicine and Primary care, The Haim Doron Division of Community Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
⁴ Community Medical Services Division, Clalit Health Services, Tel Aviv, Israel.
⁵ Department of Dermatology and Venereology, Soroka University Medical Center, Beer-Sheva, Israel.
⁶ Shaare Zedek Medical Center, the Hebrew University of Jerusalem, Jerusalem, Israel; Department of Dermatology and the Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address: tczarnowic01@rockefeller.edu.

PMID: 36343865
DOI: 10.1016/j.urology.2022.10.017

Abstract

Objective: To examine the association between chronic spontaneous urticaria (CSU) and interstitial cystitis/bladder pain syndrome (IC/BPS).

Methods: A population-based retrospective cross-sectional study was performed using the Clalit Health Services medical database. The prevalence of CSU was compared between patients diagnosed with IC/BPS and age- and gender-matched controls. Univariate analysis was performed using Chi-square and Student t test and a multivariable analysis was performed using a logistic regression model.

Results: The study included 681 patients with IC/BPS and 3376 demographically matched controls. The mean age of IC/BPS patients was 60 years old. The prevalence of CSU among patients with IC/BPS was higher as compared to the control group (20% vs 13.7%; P <.001). The adjusted OR for CSU in patients with IC/BPS was 1.58 (95% CI 1.28-1.97). Female gender and Jewish ethnicity were associated with the coexistence of these disorders (OR 1.7 95% CI 1.36-2.13, and 1.6 95% CI 1.28-2, respectively).

Conclusion: A significant association was found between IC/BPS and CSU. This finding may support the presence of allergic/immune components in the pathogenesis of IC/BPS.

MeSH terms

Chronic Urticaria* / complications
Cross-Sectional Studies
Cystitis, Interstitial* / complications
Cystitis, Interstitial* / diagnosis
Cystitis, Interstitial* / epidemiology
Female
Humans
Logistic Models
Middle Aged
Retrospective Studies