The role of lung macrophages in chronic obstructive pulmonary disease

Jianli Wu; Xia Zhao; Chuang Xiao; Guosheng Xiong; Xiulin Ye; Lin Li; Yan Fang; Hong Chen; Weimin Yang; Xiaohua Du

doi:10.1016/j.rmed.2022.107035

The role of lung macrophages in chronic obstructive pulmonary disease

Respir Med. 2022 Dec:205:107035. doi: 10.1016/j.rmed.2022.107035. Epub 2022 Oct 31.

Authors

Jianli Wu¹, Xia Zhao¹, Chuang Xiao², Guosheng Xiong³, Xiulin Ye¹, Lin Li¹, Yan Fang¹, Hong Chen¹, Weimin Yang⁴, Xiaohua Du⁵

Affiliations

¹ Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China.
² School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, 650500, China.
³ Thoracic Surgery, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China.
⁴ School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, 650500, China. Electronic address: ywmbessie@yeah.net.
⁵ Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China. Electronic address: dxiaohuabs@126.com.

PMID: 36343504
DOI: 10.1016/j.rmed.2022.107035

Abstract

Chronic obstructive pulmonary disease (COPD) as a common, preventable and treatable chronic respiratory disease in clinic, gets continuous deterioration and we can't take effective intervention at present. Lung macrophages (LMs) are closely related to the occurrence and development of COPD, but the specific mechanism is not completely clear. In this review we will focus on the role of LMs and potential avenues for therapeutic targeting for LMs in COPD.

Keywords: Airway inflammation; Chronic obstructive pulmonary disease; Lung macrophages; Treatment targets.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Lung
Macrophages, Alveolar
Pulmonary Disease, Chronic Obstructive*