Palpitations, dizziness, and syncope are common in seemingly healthy teenage girls. Unfortunately, these symptoms can raise significant concerns in the patient and family, present diagnostic challenges to health care providers, and result in unhelpful and expensive testing and unnecessary restrictions on the patient. The possibility of serious underlying pathology may prompt referral to pediatric subspecialists including cardiology. This article presents some relevant background principles and practical guidelines from the perspective of a pediatric cardiologist. Elements of initial personal and family medical history and physical examination often distinguish benign conditions from more nefarious ones, or direct limited additional testing that ultimately confirms the presence or absence of heart disease. In addition, whether these symptoms are due to a condition that is serious or benign, every patient can benefit from an intervention, sometimes simple education and reassurance, behavioral or dietary modifications, medications, invasive procedures, or referral to other health care providers. [Pediatr Ann. 2022;51(11):e440-e447.].