68Ga-FAPI and 18F-FDG PET/CT Images of a Patient With Rosai-Dorfman Disease With Liver Involvement

Zhenying Chen; Qianqian Xue; Yun Yang; Hu Shun; Weibing Miao

doi:10.1097/RLU.0000000000004367

68Ga-FAPI and 18F-FDG PET/CT Images of a Patient With Rosai-Dorfman Disease With Liver Involvement

Clin Nucl Med. 2022 Dec 1;47(12):1079-1081. doi: 10.1097/RLU.0000000000004367. Epub 2022 Aug 12.

Authors

Zhenying Chen¹, Qianqian Xue¹, Yun Yang¹, Hu Shun², Weibing Miao

Affiliations

¹ From the Departments of Nuclear Medicine.
² Pathology.

PMID: 36342795
DOI: 10.1097/RLU.0000000000004367

Abstract

Rosai-Dorfman disease is a rare non-Langerhans cell histiocytosis that is histopathologically characterized by the accumulation of CD68-positive and S100-positive histiocytes. The pathological changes are mostly discovered in lymph nodes. We report a case of Rosai-Dorfman disease with liver and bone marrow involvement. In this case, 18F-FDG PET/CT revealed FDG avidity in multiple lymph nodes, liver, and bone marrow. 68Ga-FAPI PET/CT showed higher uptake of 68Ga-FAPI than that of 18F-FDG in the same lesions. The findings of 68Ga-FAPI PET/CT in this patient highlighted the potential value of 68Ga-FAPI for staging in Rosai-Dorfman disease.

Publication types

Case Reports

MeSH terms

Fluorodeoxyglucose F18*
Histiocytosis, Sinus* / diagnostic imaging
Histiocytosis, Sinus* / pathology
Humans
Liver / diagnostic imaging
Liver / pathology
Positron Emission Tomography Computed Tomography

Substances

Fluorodeoxyglucose F18
68Ga-FAPI