The Manifestation of a Patient With Myelofibrosis in 68Ga-DOTA-FAPI-04 PET/CT Mimicking "Super Bone Imaging"

Clin Nucl Med. 2022 Dec 1;47(12):1056-1058. doi: 10.1097/RLU.0000000000004427. Epub 2022 Sep 30.

Abstract

Primary myelofibrosis is a chronic inflammatory disease of the bone marrow. It progresses from an early robust inflammatory state to a more advanced fibrotic response, representing the advanced stage of the disease. We report a 50-year-old woman who was diagnosed with primary myelofibrosis. 18F-FDG PET/CT showed mild uptake in diffuse sclerotic lesions in the bone matrix, whereas 68Ga-DOTA-FAPI-04 showed intense uptake at the whole skeleton.

Publication types

  • Case Reports

MeSH terms

  • Female
  • Fluorodeoxyglucose F18
  • Humans
  • Middle Aged
  • Positron Emission Tomography Computed Tomography*
  • Positron-Emission Tomography
  • Primary Myelofibrosis* / complications
  • Primary Myelofibrosis* / diagnostic imaging

Substances

  • 68Ga-FAPI
  • 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid
  • Fluorodeoxyglucose F18