Glomerular filtration rate abnormalities in sickle cell disease

Nowah Afangbedji; Marina Jerebtsova

doi:10.3389/fmed.2022.1029224

Glomerular filtration rate abnormalities in sickle cell disease

Front Med (Lausanne). 2022 Oct 21:9:1029224. doi: 10.3389/fmed.2022.1029224. eCollection 2022.

Authors

Nowah Afangbedji¹, Marina Jerebtsova²

Affiliations

¹ Department of Physiology and Biophysics, Howard University, Washington, DC, United States.
² Department of Microbiology, Howard University, Washington, DC, United States.

Abstract

Sickle cell disease (SCD) is a group of inherited blood disorders affecting the β-globin gene, resulting in the polymerization of hemoglobin and subsequent sickling of the red blood cell. Renal disease, the most common complication in SCD, begins in childhood with glomerular hyperfiltration and then progresses into albuminuria, a fast decline of glomerular filtration, and renal failure in adults. This mini-review focuses on glomerular filtration abnormalities and the mechanisms of hyperfiltration, explores genetic modifiers and methods of estimating glomerular filtration rates, and examines novel biomarkers of glomerular filtration in SCD.

Keywords: biomarkers; chronic kidney disease; glomerular filtration; hyperfiltration; sickle cell disease; sickle cell nephropathy.

Publication types

Review