N-(4-Hy-droxy-2-nitro-phen-yl)acetamide

James E Hines Iii; Curtistine J Deere; Frank R Fronczek; Rao M Uppu

doi:10.1107/S2414314622002012

N-(4-Hy-droxy-2-nitro-phen-yl)acetamide

IUCrdata. 2022 Feb 25;7(Pt 2):x220201. doi: 10.1107/S2414314622002012. eCollection 2022 Feb.

Authors

James E Hines Iii¹, Curtistine J Deere¹, Frank R Fronczek², Rao M Uppu¹

Affiliations

¹ Department of Environmental Toxicology, College of Agriculture, Southern University and A&M College, Baton Rouge, LA 70813, USA.
² Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA.

Abstract

The title compound, C₈H₈N₂O₄, differs in its degree of planarity from the 3-nitro isomer and also in its hydrogen-bonding pattern. Its NH group forms an intra-molecular hydrogen bond to a nitro oxygen atom, and its OH group forms an inter-molecular hydrogen bond to an amide oxygen atom, generating [10] chains in the crystal.

Keywords: crystal structure; hydrogen bonding.

Grants and funding

The authors acknowledge the support from the National Institutes of Health (NIH) through the National Institute of General Medical Science (NIGMS) grant No. 5 P2O GM103424–17 and the US Department of Education (US DoE; Title III, HBGI Part B grant No. P031B040030). Its contents are solely the responsibility of authors and do not represent the official views of NIH, NIGMS, or US DoE. The upgrade of the diffractometer was made possible by grant No. LEQSF(2011–12)-ENH-TR-01, administered by the Louisiana Board of Regents.