Diethyl 3,3'-[(3-fluoro-phen-yl)methyl-ene]bis-(1 H-indole-2-carboxyl-ate)

Hong Jiang; Yu-Long Li; Jin Zhou; Hong-Shun Sun; Qing-Yu Zhang; Xing-Hao Shi; Zhi-Yuan Zhang; Tian Ling

doi:10.1107/S2414314620009128

Diethyl 3,3'-[(3-fluoro-phen-yl)methyl-ene]bis-(1 H-indole-2-carboxyl-ate)

IUCrdata. 2020 Jul 10;5(Pt 7):x200912. doi: 10.1107/S2414314620009128. eCollection 2020 Jul.

Authors

Hong Jiang¹, Yu-Long Li¹, Jin Zhou^{1

2}, Hong-Shun Sun¹, Qing-Yu Zhang¹, Xing-Hao Shi¹, Zhi-Yuan Zhang¹, Tian Ling¹

Affiliations

¹ Targeted MRI Contrast Agents Laboratory of Jiangsu Province, Nanjing Polytechnic Institute, Nanjing 210048, People's Republic of China.
² College of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, People's Republic of China.

Abstract

In the title compound, C₂₉H₂₅FN₂O₄, the mean planes of the indole ring systems are approximately perpendicular to one another [dihedral angle = 88.3 (4)°]. The benzene ring is twisted with respect to the indole ring systems by 49.8 (5) and 77.6 (3)°. In the crystal, pairs of N-H⋯O hydrogen bonds link the mol-ecules into the inversion dimers which are further linked into supra-molecular chains propagating along the [110] direction.

Keywords: MRI; bisindole; contrast agents; crystal structure.

Grants and funding

Funding for this research was provided by: Natural Science Foundation of Jiangsu Province (grant No. BK20181486); Natural Science Foundation of the Jiangsu Higher Education Institutions (grant No. 17KJB320001); Training program of Students Innovation and Entrepreneurship in Jiangsu Province (grant No. 201812920002Y); Overseas Training Program for Excellent Young Teachers and Principals of Jiangsu Province; Qing Lan Project of Jiangsu Province; Natural Science Foundation of Nanjing Polytechnic Institute (grant No. NHKY-2019-07).