Grape exosome-like nanoparticles: A potential therapeutic strategy for vascular calcification

Yintong Teng; Jiaqi He; Qingping Zhong; Yangmei Zhang; Zhenxing Lu; Tianwang Guan; Yuxuan Pan; Xiaodi Luo; Weijing Feng; Caiwen Ou

doi:10.3389/fphar.2022.1025768

Grape exosome-like nanoparticles: A potential therapeutic strategy for vascular calcification

Front Pharmacol. 2022 Oct 21:13:1025768. doi: 10.3389/fphar.2022.1025768. eCollection 2022.

Authors

Yintong Teng^{1

2}, Jiaqi He², Qingping Zhong^{1

2}, Yangmei Zhang^{1

2}, Zhenxing Lu^{1

2}, Tianwang Guan², Yuxuan Pan^{1

2}, Xiaodi Luo³, Weijing Feng⁴, Caiwen Ou¹

Affiliations

¹ Department of Cardiology, Guangdong Provincial Key Laboratory of Shock and Microcirculation, Dongguan Hospital of Southern Medical University, Southern Medical University, Guangzhou, China.
² Department of Cardiology, Laboratory of Heart Center, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
³ Department of Cardiothoracic Surgery, 920th Hospital of Joint Logistics Support Force of People's Liberation Army of China, Kunming, China.
⁴ Department of Cardiology, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Lab of Shock and Microcirculation, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Abstract

Vascular calcification (VC) is prevalent in hypertension, diabetes mellitus, chronic kidney disease, and aging and has been identified as an important predictor of adverse cardiovascular events. With the complicated mechanisms involved in VC, there is no effective therapy. Thus, a strategy for attenuating the development of VC is of clinical importance. Recent studies suggest that grape exosome-like nanoparticles (GENs) are involved in cell-cell communication as a means of regulating oxidative stress, inflammation, and apoptosis, which are known to modulate VC development. In this review, we discuss the roles of GENs and their potential mechanisms in the development of VC.

Keywords: exosomes; grape exosome-like nanoparticles; osteogenic phenotype differentiation; vascular calcification; vascular smooth muscle cells.

Publication types

Review