Association between sedentary behavior, physical activity, and cardiovascular disease-related outcomes in adults-A meta-analysis and systematic review

Zhi-de Liang; Meng Zhang; Chuan-Zhi Wang; Yang Yuan; Jing-Hong Liang

doi:10.3389/fpubh.2022.1018460

Association between sedentary behavior, physical activity, and cardiovascular disease-related outcomes in adults-A meta-analysis and systematic review

Front Public Health. 2022 Oct 19:10:1018460. doi: 10.3389/fpubh.2022.1018460. eCollection 2022.

Authors

Zhi-de Liang¹, Meng Zhang², Chuan-Zhi Wang³, Yang Yuan¹, Jing-Hong Liang⁴

Affiliations

¹ Cancer Institute of The Affiliated Hospital of Qingdao University and Qingdao Cancer Institute, Qingdao, China.
² Postgraduate Department, Xi'an Physical Education University, Xi'an, China.
³ Department of Physical Education, College of Physical Education, Qingdao University, Qingdao, China.
⁴ Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, China.

Abstract

Background: Sedentary behavior (SB) and physical activity (PA) are modifiable risk factors for cardiovascular disease (CVD); however, previous research on the effects of PA and SB on CVD has been relatively homogeneous. Our study investigated the association between PA, SB, and CVD-related outcomes.

Methods: A comprehensive search strategy was conducted in the MEDLINE, Embase, Cochrane Library, and Web of Science databases from their inception to September 2022. We identified eligible studies according to PICOS: the populations comprised healthy adults, the interventions or exposures were PA or SB, the outcomes were CVD-related outcomes, and the study designs were randomized controlled trials (RCTs) and longitudinal studies (LS). Outcomes were pooled using fixed or random effects models, and the quality of individual studies was assessed by the Cochrane Risk of Bias Instrument and the Newcastle Ottawa Scale.

Results: A total of 148 RCTs and 36 LS were included, comprising a total of 75,075 participants. The study quality was rated as low to moderate. We found an increased hazard ratio (HR) for CVD in the population with SB (HR = 1.34; 95% confidence interval [CI]: 1.26 to 1.43; I² = 52.3%; P_{heterogeneity} < 0.001, random model) and a decreased HR for CVD in those who performed long-term PA (HR = 0.71; 95% CI: 0.66 to 0.77; I² = 78.0%, P_{heterogeneity} < 0.001, random model). Long-term PA improved the lipid profiles in healthy adults; participants in this group exhibited increased high-density lipoprotein (weighted mean difference [WMD] = 2.38; 95% CI: 1.00 to 3.76; I² = 84.7%; P_{heterogeneity} < 0.001, random model), decreased triglycerides (WMD = -7.27; 95% CI: -9.68 to -4.87; I² = 0%, P_{heterogeneity} = 0.670, fixed model), and lower total-cholesterol (WMD = -6.84; 95% CI: -9.15 to -4.52; I² = 38.4%, P_{heterogeneity} < 0.001, random model).

Conclusions: Long-term SB increases the risk of CVD in healthy adults, whereas PA reduces the risk of CVD and improves indicators associated with CVD. However, the ability of PA to improve blood lipids appeared to be limited. The detailed association of SB and PA on CVD needs to be further investigated in the future.

Keywords: cardiovascular disease(s); healthy adult; meta-analysis; physical activity; sedentary behavior.

Publication types

Meta-Analysis
Systematic Review
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Cardiovascular Diseases* / epidemiology
Exercise
Humans
Primary Prevention
Randomized Controlled Trials as Topic
Sedentary Behavior*
Triglycerides

Substances

Triglycerides