An updated analysis of the association between CD2-associated protein gene rs9349407 polymorphism and Alzheimer's disease in Chinese population

Shan Gao; Jia-Wei Hao; Ya-Nan Zhao; Xuan Li; Tao Wang; Zhi-Fa Han; Bao-Liang Sun; Jing-Yi Sun; Gui-You Liu

doi:10.3389/fninf.2022.1006164

An updated analysis of the association between CD2-associated protein gene rs9349407 polymorphism and Alzheimer's disease in Chinese population

Front Neuroinform. 2022 Oct 20:16:1006164. doi: 10.3389/fninf.2022.1006164. eCollection 2022.

Authors

Shan Gao¹, Jia-Wei Hao², Ya-Nan Zhao¹, Xuan Li¹, Tao Wang³, Zhi-Fa Han⁴, Bao-Liang Sun⁵, Jing-Yi Sun⁶, Gui-You Liu^{1

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Affiliations

¹ Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China.
² Department of Interventional Radiology and Vascular Surgery, Affiliated Hospital of Hebei University, Baoding, Hebei, China.
³ Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
⁴ School of Medicine, School of Pharmaceutical Sciences, Tsinghua University-Peking University Center for Life Sciences, Tsinghua University, Beijing, China.
⁵ Shandong Academy of Medical Sciences, The Second Affiliated Hospital, Shandong First Medical University, Taian, Shandong, China.
⁶ Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
⁷ Beijing Key Laboratory of Hypoxia Translational Medicine, National Engineering Laboratory of Internet Medical Diagnosis and Treatment Technology, Xuanwu Hospital, Capital Medical University, Beijing, China.

Abstract

Background: Since 2011, three large-scale genome-wide association studies (GWAS) have confirmed that the CD2AP rs9349407 polymorphism is significantly connected with Alzheimer's disease (AD) in individuals of European descent. Subsequently, this association has been replicated in European populations, but is unclear whether it can be replicated in Chinese. Recently, the correlation between rs9349407 and AD in the Chinese population has become a research hotspot.

Objective: To explore the association between rs9349407 polymorphism and AD in the Chinese population.

Materials and methods: Firstly, based on the exclusion and inclusion criteria, we selected 11 independent studies from 8 articles exploring the correlation between rs9349407 variation and AD in Chinese. Secondly, we conducted a meta-analysis based on fixed and random effect models and conducted a heterogeneity test. Thirdly, we used the additive model, dominant model, and recessive model for subgroup analysis.

Results: We demonstrated that the CD2AP rs9349407 polymorphism increases AD susceptibility in Chinese populations (OR = 1.33, 95% CI = 1.08-1.64, P = 7.45E-03), which is consistent with the effect observed in Caucasian populations. Additionally, subgroup analysis showed that rs9349407 under the additive model (GG + CC vs. GC, OR = 0.76, 95% CI = 0.61-0.97, P = 2.04E-02) and dominant model (GG + GC vs. CC, OR = 0.49, 95% CI = 0.32-0.74, P = 8.51E-04) were also significantly correlated with AD susceptibility, but not under the recessive model (GG vs. GC + CC, OR = 0.77, 95% CI = 0.58-1.03, P = 7.44E-02).

Conclusion: These existing data suggest that rs9349307 is significantly correlated with the susceptibility to AD in the Chinese population, but future studies with large samples are needed to confirm our findings.

Keywords: Alzheimer’s disease (AD); CD2-associated protein (CD2AP); Chinese population; genome-wide association studies (GWAS); meta-analysis; rs9349307 polymorphism.