1-{3-[(7-Fluoro-9 H-pyrimido[4,5- b]indol-4-yl)(meth-yl)amino]-piperidin-1-yl}propan-1-one

Stanislav Andreev; Dieter Schollmeyer; Pierre Koch

doi:10.1107/S2414314621001590

1-{3-[(7-Fluoro-9 H-pyrimido[4,5- b]indol-4-yl)(meth-yl)amino]-piperidin-1-yl}propan-1-one

IUCrdata. 2021 Feb 23;6(Pt 2):x210159. doi: 10.1107/S2414314621001590. eCollection 2021 Feb.

Authors

Stanislav Andreev¹, Dieter Schollmeyer², Pierre Koch¹

Affiliations

¹ Institute of Pharmaceutical Sciences, Department of Pharmaceutical and Medicinal Chemistry, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany.
² Department of Organic Chemistry, Johannes Gutenberg Universität Mainz, Duesbergweg 10-14, 55099 Mainz, Germany.

Abstract

The title compound, C₁₉H₂₂FN₅O, has been synthesized as an inhibitor of glycogen synthase kinase-3β. Two mol-ecules inter-act via two N-H⋯N hydrogen bonds, forming centrosymmetric dimers.

Keywords: crystal structure; kinase inhibitor; pyrimidoindole.