4'-phosphopantetheine acts as a potential antioxidant to limit atherosclerotic plaque formation by inhibiting ROS generation

Taiyu Zhai; Wenbo Ren; Pingping Wang; Xiumei Hu; Jingyu Wang; Lei Zheng

doi:10.3389/fphys.2022.989105

4'-phosphopantetheine acts as a potential antioxidant to limit atherosclerotic plaque formation by inhibiting ROS generation

Front Physiol. 2022 Oct 21:13:989105. doi: 10.3389/fphys.2022.989105. eCollection 2022.

Authors

Taiyu Zhai¹, Wenbo Ren², Pingping Wang¹, Xiumei Hu¹, Jingyu Wang¹, Lei Zheng¹

Affiliations

¹ Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
² Department of Clinical Laboratory, The First Hospital of Jilin University, Jilin University, Changchun, China.

Abstract

Coronary heart disease (CHD) is caused by coronary atherosclerosis and has a high morbidity and mortality rate worldwide. There are challenges in both early screening and treatment of CHD. The appearance and development of CHD is a complex metabolic disorder process. Therefore, to search for new biomarkers of CHD, we analyzed the peripheral blood metabolome in patients with CHD. In the study, a plasma metabolite, 4'-Phosphopantetheine (4-PPanSH), which was discovered by HPLC-MS/MS, as peripheral blood 4-PPanSH decreases, the degree of coronary blockage gradually aggravates. In addition, the 4-PPanSH supplement limited atherosclerotic plaque formation and endothelial injury in mice. Further, in vascular endothelial cells, 4-PPanSH effectively inhibited ROS generation and ox-LDL accumulation. In summary, 4-PPanSH was associated with the degree of coronary stenosis, and the 4-PPanSH supplement reduced atherosclerotic plaque generation, which could be associated with 4-PPanSH acting as a potent antioxidant that inhibits ROS generation and alleviates vascular endothelial injury.

Keywords: 4′-phosphopantetheine; ROS; antioxidant; coronary heart disease; vascular endothelial injury.