Association between the ratio of serum creatinine to cystatin C and bone mineral density in Chinese older adults patients with type 2 diabetes mellitus

Ting Gao; Fupeng Liu; Bo Ban; Yue Hou; Guangxin Li; Mingming Jiang; Qing Yang; Mei Zhang

doi:10.3389/fnut.2022.1035853

Association between the ratio of serum creatinine to cystatin C and bone mineral density in Chinese older adults patients with type 2 diabetes mellitus

Front Nutr. 2022 Oct 21:9:1035853. doi: 10.3389/fnut.2022.1035853. eCollection 2022.

Authors

Ting Gao¹, Fupeng Liu², Bo Ban², Yue Hou¹, Guangxin Li¹, Mingming Jiang¹, Qing Yang³, Mei Zhang²

Affiliations

¹ Department of Clinical Medicine, Jining Medical University, Jining, Shandong, China.
² Department of Endocrinology, Affiliated Hospital of Jining Medical University, Jining, Shandong, China.
³ Department of Nutrition, Affiliated Hospital of Jining Medical University, Jining, Shandong, China.

Abstract

Background: The ratio of creatinine to cystatin C (Cre/CysC), a marker of muscle function and muscle mass, can be used to predict sarcopenia in different populations. Since sarcopenia is closely associated with osteoporosis, this study investigated the association between Cre/CysC and bone mineral density (BMD) in patients with type 2 diabetes mellitus (T2DM).

Method: This cross-sectional study included 391 Chinese patients with T2DM. General information, biochemical indicators, and the BMD of lumbar spine (LS), femoral neck (FN), and total hip (TH) were measured.

Results: Pearson correlation analysis showed that Cre/CysC was significantly positively correlated with the BMD of LS (r = 0.170, p = 0.001), FN (r = 0.178, p < 0.001), and TH (r = 0.205, p < 0.001). The results of stepwise linear regression suggested that Cre/CysC was the only biochemical predictor of the BMD at three sites (LS: β = 0.137, p = 0.01; FN: β = 0.097, p = 0.038; TH: β = 0.145, p = 0.002).

Conclusion: In older patients with T2DM, high Cre/CysC value is independently positively associated with BMD and hence, Cre/CysC may serve as a valuable marker of osteoporosis.

Keywords: Cre/CysC; bone mineral density; creatinine; cystatin C; type 2 diabetes.