Exosomes as Anticancer Drug Delivery Vehicles: Prospects and Challenges

Yubo Zhang; Jian Li; Wei Gao; Na Xie

doi:10.31083/j.fbl2710293

Exosomes as Anticancer Drug Delivery Vehicles: Prospects and Challenges

Front Biosci (Landmark Ed). 2022 Oct 27;27(10):293. doi: 10.31083/j.fbl2710293.

Authors

Yubo Zhang¹, Jian Li¹, Wei Gao², Na Xie¹

Affiliations

¹ State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, and Collaborative Innovation Center for Biotherapy, 610041 Chengdu, Sichuan, China.
² Clinical Genetics Laboratory, Affiliated Hospital & Clinical Medical College of Chengdu University, 610081 Chengdu, Sichuan, China.

PMID: 36336863
DOI: 10.31083/j.fbl2710293

Abstract

Exosomes, a subset of extracellular vesicles, are widely present in various body fluids and are involved in mediating intercellular communication. They have received extensive attention as diagnostic markers. The excellent physicochemical and biological properties of exosomes make them great potential drug delivery vehicles for the treatment of cancer and other diseases. However, various challenges need to be addressed for the clinical application of exosomes. This review introduces the biogenesis and uptake of exosomes and compares different approaches for isolation and drug loading, focusing on the application and current challenges of exosomes as drug delivery vehicles in cancer therapy.

Keywords: cancer; drug delivery; exosomes.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents* / therapeutic use
Drug Delivery Systems
Exosomes*
Extracellular Vesicles*
Humans
Neoplasms* / diagnosis
Neoplasms* / drug therapy

Substances

Antineoplastic Agents