Mechanical force induced DNA double-strand breaks: Ultrasound

Yue Ma; Iwaki Akiyama

doi:10.1016/bs.enz.2022.08.004

Mechanical force induced DNA double-strand breaks: Ultrasound

Enzymes. 2022:51:53-63. doi: 10.1016/bs.enz.2022.08.004. Epub 2022 Sep 27.

Authors

Yue Ma¹, Iwaki Akiyama²

Affiliations

¹ Faculty of Life and Medical Science, Doshisha University, Kyotanabe, Japan; Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China. Electronic address: mayue@bme.cams.cn.
² Faculty of Life and Medical Science, Doshisha University, Kyotanabe, Japan.

PMID: 36336408
DOI: 10.1016/bs.enz.2022.08.004

Abstract

Since the application of ultrasound for clinical diagnosis and therapeutic purposes has been increased rapidly, the effects of exposure to ultrasound on DNA molecules were studied. In this chapter, we introduced various effects of DNA damages caused by different conditions of exposure of ultrasound. Ultrasound with different sound pressure and pulse transmission conditions have been applied in our study. We discussed the threshold of sound pressure of ultrasound-induced DNA damages. Different kinds of pulses of ultrasound and microbubbles' influences on DNA double-strand breaks were also shown.

Keywords: Cavitations; DNA damage; Exposure to ultrasound; Genome-sized DNA; Pulse transmission conditions; Sound pressure.

MeSH terms

DNA Damage*
DNA* / genetics

Substances

DNA