G3BP2: Structure and function

Pharmacol Res. 2022 Dec:186:106548. doi: 10.1016/j.phrs.2022.106548. Epub 2022 Nov 3.

Abstract

Ras-GAP SH3 domain binding proteins (G3BPs) are a family of RNA-binding proteins that include G3BP1 and G3BP2 in mammals. The protein structure of G3BP2 allows it to bind with RNA or protein and regulate the nucleoplasmic shuttle, therefore participating in a variety of biological functions such as cell growth, differentiation and migration, and RNA and protein metabolism. G3BP2 is abnormally expressed in many tumors and diseases, such as breast cancer, lung cancer, prostate cancer, cardiac hypertrophy, and atherosclerosis. Many researchers have found that G3BP2 may be a potential therapeutic target. In this review, we examine the structure and expression regulation of G3BP2, and further summarize the function of G3BP2 from three aspects: RNA stabilization, protein subcellular localization, and stress granules assembling to provide a broader understanding of the role of G3BP2.

Keywords: G3BP2; NFκB; RNA binding; Stress granules; Subcellular location; Tumor.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptor Proteins, Signal Transducing / metabolism
  • Animals
  • Breast Neoplasms* / metabolism
  • Carrier Proteins / metabolism
  • DNA Helicases* / genetics
  • DNA Helicases* / metabolism
  • Humans
  • Male
  • Mammals / genetics
  • Mammals / metabolism
  • Poly-ADP-Ribose Binding Proteins / genetics
  • RNA
  • RNA Helicases / metabolism
  • RNA Recognition Motif Proteins / metabolism
  • RNA-Binding Proteins

Substances

  • RNA Recognition Motif Proteins
  • Poly-ADP-Ribose Binding Proteins
  • DNA Helicases
  • RNA Helicases
  • Carrier Proteins
  • RNA
  • G3BP1 protein, human
  • G3BP2 protein, human
  • RNA-Binding Proteins
  • Adaptor Proteins, Signal Transducing