Ancestry-defined molecular taxonomy of prostate cancer

Isra Elhussin; Clayton Yates

doi:10.1016/j.trecan.2022.10.008

Ancestry-defined molecular taxonomy of prostate cancer

Trends Cancer. 2022 Dec;8(12):973-975. doi: 10.1016/j.trecan.2022.10.008. Epub 2022 Nov 3.

Authors

Isra Elhussin¹, Clayton Yates²

Affiliations

¹ Department of Biology and Center for Cancer Research, Tuskegee University, Tuskegee, AL, USA.
² Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: cyates10@jhmi.edu.

PMID: 36335083
DOI: 10.1016/j.trecan.2022.10.008

Abstract

Recent studies by Gong et al. and Jaratlerdsiri et al. re-evaluate the mutational landscape of prostate cancer (PCa) in a global context based on ancestry. These two studies revealed African-specific PCa taxonomy, including novel oncogenic drivers with promising therapeutic targets and the opportunity to predict patient outcomes using a unified pipeline.

Keywords: African ancestry; genomic alterations; prostate cancer.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Black People
Carcinogenesis
Humans
Male
Mutation
Prostatic Neoplasms* / genetics
Prostatic Neoplasms* / therapy

Abstract

Publication types

MeSH terms

Grants and funding