Molecular and clinical characterization of H3 K27M-mutant "non-midline" glioblastoma: A case report and literature review

Shumpei Onishi; Shinji Ohba; Kazuya Kuraoka; Takashi Kurashige; Kazuhiko Sugiyama; Fumiyuki Yamasaki

doi:10.1016/j.neucie.2021.06.008

Molecular and clinical characterization of H3 K27M-mutant "non-midline" glioblastoma: A case report and literature review

Neurocirugia (Astur : Engl Ed). 2022 Nov-Dec;33(6):356-360. doi: 10.1016/j.neucie.2021.06.008.

Authors

Shumpei Onishi¹, Shinji Ohba², Kazuya Kuraoka³, Takashi Kurashige⁴, Kazuhiko Sugiyama⁵, Fumiyuki Yamasaki⁶

Affiliations

¹ Department of Neurosurgery, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Hiroshima, Japan; Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan. Electronic address: shumpei.ohnishi@gmail.com.
² Department of Neurosurgery, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Hiroshima, Japan.
³ Department of Diagnostic Pathology, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Hiroshima, Japan.
⁴ Department of Neurology, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Hiroshima, Japan.
⁵ Department of Clinical Oncology and Neuro-oncology Program, Hiroshima University Hospital, Hiroshima, Japan.
⁶ Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan. Electronic address: fyama@hiroshima-u.ac.jp.

PMID: 36333093
DOI: 10.1016/j.neucie.2021.06.008

Abstract

The WHO classification of tumors of the CNS in 2016 defined "diffuse midline glioma, H3 K27M-mutant" as a new tumor entity locating in the CNS midline. However, the H3 K27M-mutation in "non-midline" glioblastoma are rare and their characteristics have been rarely reported. A 16-year-old girl presented a hyper-intense lesion at her left temporal stem on T2WI, FLAIR and DWI. Biopsy was performed and molecular pathological diagnosis was glioblastoma with H3 K27M-mutant. Accordingly, the possibility of H3 K27M-mutant should be examined not only for diffuse glioma without IDH mutation that develops at a midline location, but also in non-midline locations.

Keywords: Glioblastoma; H3K27M-mutation; Mutación H3K27M; No línea media; Non-midline.

Publication types

Review
Case Reports

MeSH terms

Adolescent
Brain Neoplasms* / diagnostic imaging
Brain Neoplasms* / genetics
Brain Neoplasms* / pathology
Female
Glioblastoma* / diagnostic imaging
Glioblastoma* / genetics
Glioma* / pathology
Histones / genetics
Humans
Mutation

Substances

Histones