A case of restitution ad integrum in Gorham-Stout disease

Joint Bone Spine. 2023 Jan;90(1):105478. doi: 10.1016/j.jbspin.2022.105478. Epub 2022 Nov 1.

Abstract

Gorham-Stout disease (or "vanishing bone" disease) is a rare mono or polyostotic disease of unknown etiology, characterized by intraosseous angiomatous proliferation leading to bone resorption. We report the case of a 17-year-old woman presenting with symptomatic osteolytic lesions of the frontal vault. Imaging was suggestive of Gorham-Stout disease without argument for other diagnoses. An unusual evolution of the "vanishing bone" lesions was observed on the scan after one year, with a full recovery of the lytic lesions. This report shows for the first time a spontaneous restitutio ad integrum of bone matrix in Gorham-Stout disease.

Keywords: Gorham-Stout; Vanishing bone.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Bone Diseases*
  • Bone Resorption*
  • Female
  • Humans
  • Osteolysis, Essential* / diagnostic imaging