TERRA and RAD51AP1 at the R&D-loop department of ALT telomeres

Anabelle Decottignies

doi:10.1016/j.molcel.2022.10.006

TERRA and RAD51AP1 at the R&D-loop department of ALT telomeres

Mol Cell. 2022 Nov 3;82(21):3963-3965. doi: 10.1016/j.molcel.2022.10.006.

Author

Anabelle Decottignies¹

Affiliation

¹ Genetic and Epigenetic Alterations of Genomes, Telomere Research Group, de Duve Institute, UCLouvain, Brussels, Belgium. Electronic address: anabelle.decottignies@uclouvain.be.

PMID: 36332602
DOI: 10.1016/j.molcel.2022.10.006

Abstract

In this issue of Molecular Cell, Kaminski et al. and Yadav et al. demonstrate that RAD51AP1 and TERRA non-coding RNA positively regulate the alternative mechanism of telomere maintenance by promoting D-loop formation and chromatin-directed mechanisms to suppress transcription-collision events during ALT telomere synthesis.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Chromatin
R-Loop Structures
RNA, Long Noncoding* / genetics
Telomere / genetics
Telomere Homeostasis*

Substances

RNA, Long Noncoding
Chromatin