Background: This study aimed to retrospectively evaluate a large Chinese cohort's baseline characters and develop a new predictive scoring system.
Methods: A total of 491 FL patients were reviewed, and 337newly diagnosed 1-3a FL patients from January 2010 to October 2020 were enrolled in our retrospective cohort.
Results: Progression-free survival (PFS) was assessed as the first endpoint; the 2-year and 5-year PFS were 81.4% and 67.8%, respectively. A new risk scoring system (SLMR) was established after the univariable and multivariable analyses, and four independent factors such as β2-MG, LDH, LMR, the number of nodal areas ≥ 5, and spleen involvement were detected by FDG-PET imaging were included. The SLMR was compared with the existing models using discrimination and calibration, and k-fold cross-validation was performed for internal validation. Our cohort classified patients into three groups (low-, intermediate- and high) according to the SLMR and showed the best model performance, especially for FL3a and received rituximab maintenance after induction therapy patients.
Keywords: Follicular lymphoma; Prognosis; Risk scoring system; Spleen involvement; The lymphocyte/monocyte ratio.
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