In this article, an event-triggered (ET) fractional-order adaptive tracking control scheme (ATCS) is studied for the uncertain nonlinear system with the output saturation and the external disturbances by using the nonlinear disturbance observer (NDO) and the neural networks (NNs). Based on NNs, the system uncertainties are approximated. An NN-based NDO is designed to estimate the bounded disturbances. Combining the NNs, the output of the designed NDO, the fractional-order theory, and the ET mechanism, an ATCS is proposed under the output saturation. According to the stability analysis, all the closed-loop signals are semiglobally uniformly ultimately bounded based on the investigative ATCS. The simulation results and the comparative experiment verifications are shown to indicate the viability of the developed control scheme.