Using Stem Cells to Treat Diabetes-Induced Infertility

Fatemeh Abedini; Fariba Giassi; Reza Rahbarghazi; Golamreza Hamidian; Rana Keyhanmanesh

doi:10.2174/1573399819666221103143710

Using Stem Cells to Treat Diabetes-Induced Infertility

Curr Diabetes Rev. 2023;19(7):e031122210620. doi: 10.2174/1573399819666221103143710.

Authors

Fatemeh Abedini¹, Fariba Giassi¹, Reza Rahbarghazi^{2

3}, Golamreza Hamidian⁴, Rana Keyhanmanesh¹

Affiliations

¹ Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
² Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
³ Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
⁴ Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.

PMID: 36330635
DOI: 10.2174/1573399819666221103143710

Abstract

Diabetes is one of the main causes of infertility, which impacts the quality of life of couples. These reproductive complications are important issues for all clinicians. The strategies for the treatment of diabetes-induced infertility are limited with the high cost and unsatisfied results. Due to the multi-directional differentiation potential and self-renewal ability of stem cells, these cells have emerged as attractive therapeutic agents in many diseases, including diabetes mellitus. We reviewed the current knowledge on the best available evidence regarding the role of stem cell transplantation in reproductive complications of diabetes.

Keywords: Stem cells; diabetes; hypothalamus-pituitary-gonadal axis; infertility; sexual behaviors; spermatogenesis.

Publication types

Review

MeSH terms

Diabetes Mellitus* / therapy
Humans
Infertility, Male* / etiology
Infertility, Male* / therapy
Male
Quality of Life
Stem Cell Transplantation / adverse effects