Targeting lactate-related cell cycle activities for cancer therapy

Jia Lin; Geng Liu; Lidian Chen; Hang Fai Kwok; Yao Lin

doi:10.1016/j.semcancer.2022.10.009

Targeting lactate-related cell cycle activities for cancer therapy

Semin Cancer Biol. 2022 Nov;86(Pt 3):1231-1243. doi: 10.1016/j.semcancer.2022.10.009. Epub 2022 Oct 31.

Authors

Jia Lin¹, Geng Liu², Lidian Chen³, Hang Fai Kwok⁴, Yao Lin⁵

Affiliations

¹ Central Laboratory at the Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine, Collaborative Innovation Center for Rehabilitation Technology, the Institute of Rehabilitation Industry, Fujian University of Traditional Chinese Medicine, China; Collaborative Innovation Center for Rehabilitation Technology, the Institute of Rehabilitation Industry, Fujian University of Traditional Chinese Medicine, China.
² Laboratory of Cancer Biology, Department of Oncology, University of Oxford, UK.
³ Collaborative Innovation Center for Rehabilitation Technology, the Institute of Rehabilitation Industry, Fujian University of Traditional Chinese Medicine, China. Electronic address: cld@fjtcm.edu.cn.
⁴ Cancer Centre, Faculty of Health Sciences, University of Macau, Avenida da Universidade, Taipa, Macau SAR; MoE Frontiers Science Center for Precision Oncology, University of Macau, Avenida de Universidade, Taipa, Macau SAR; Department of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Avenida da Universidade, Taipa, Macau SAR. Electronic address: hfkwok@um.edu.mo.
⁵ Central Laboratory at the Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine, Collaborative Innovation Center for Rehabilitation Technology, the Institute of Rehabilitation Industry, Fujian University of Traditional Chinese Medicine, China; Fujian-Macao Science and Technology Cooperation Base of Traditional Chinese Medicine-Oriented Chronic Disease Prevention and Treatment, Innovation and Transformation Center, Fujian University of Traditional Chinese Medicine, China. Electronic address: yaolin@fjtcm.edu.cn.

PMID: 36328311
DOI: 10.1016/j.semcancer.2022.10.009

Abstract

Lactate has long been considered as a metabolic by-product of aerobic glycolysis for cancer. However, more and more studies have shown that lactate can regulate cancer progression via multiple mechanisms such as cell cycle regulation, immune suppression, energy metabolism and so on. A recent discovery of lactylation attracted a lot of attention and is already a hot topic in the cancer field. In this review, we summarized the latest functions of lactate and its underlying mechanisms in cancer. We also included our analysis of protein lactylation in different rat organs and compared them with other published lactylation data. The unresolved challenges in this field were discussed, and the potential application of these new discoveries of lactate-related cell cycle activities for cancer target therapy was speculated.

Keywords: Cancer; Cell cycle; Lactate; Lactylation; Warburg effect.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Cycle / genetics
Citric Acid Cycle
Energy Metabolism
Humans
Lactic Acid*
Neoplasms* / therapy
Rats

Substances

Lactic Acid