Metabonomics and the gut microbiome analysis of the effect of 6-shogaol on improving obesity

Wenya Jiao; Yaxin Sang; Xianghong Wang; Shuo Wang

doi:10.1016/j.foodchem.2022.134734

Metabonomics and the gut microbiome analysis of the effect of 6-shogaol on improving obesity

Food Chem. 2023 Mar 15;404(Pt B):134734. doi: 10.1016/j.foodchem.2022.134734. Epub 2022 Oct 28.

Authors

Wenya Jiao¹, Yaxin Sang¹, Xianghong Wang¹, Shuo Wang²

Affiliations

¹ College of Food Science and Technology, Hebei Agricultural University, Baoding 071000, China.
² Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin, 9300071, China.

PMID: 36327507
DOI: 10.1016/j.foodchem.2022.134734

Abstract

This study investigated the ability of 6-shogaol to reduce obesity in C57BL/6J mice fed with high-fat diet (HFD). After 12 weeks of 6-shogaol (20, 40, 60 mg/kg/2 days) intervention, obesity related indicators, gut microbiota and metabonomics of mice were analyzed. The obesity degree and blood lipid level of mice treated with 6-shogaol were reduced, and glucose homeostasis was improved, especially in mice treated with low-dose. The intervention of 6-shogaol increased the diversity of gut microbiota and decreased the ratio of Firmicutes and Bacteroides. 6-shogaol also led to changes in metabonomics. There were 5, 4 and 6 different metabolites of 6-shogaol at low, medium and high doses. Among them, Solacauline, PE (22:5 (4Z, 7z, 10z, 13z, 13z, 16z)/14:1 (9z)) and presqualene diphosphate have strong correlation with Akkermansia, Brucella, Odoribacter and Mucispirillum. This study aims to provide a theoretical foundation for clarifying the molecular mechanism of 6-shogaol in improving obesity.

Keywords: 6-Shogaol; Anti-obesity; Gut microbiome; Metabolomics.

MeSH terms

Animals
Diet, High-Fat / adverse effects
Gastrointestinal Microbiome*
Metabolomics
Mice
Mice, Inbred C57BL
Obesity / drug therapy
Obesity / genetics

Substances

shogaol