Curcumin Inhibits Invasion and Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma Cells by Regulating TET1/Wnt/β-catenin Signal Axis

Bull Exp Biol Med. 2022 Oct;173(6):770-774. doi: 10.1007/s10517-022-05629-6. Epub 2022 Nov 2.

Abstract

The molecular mechanisms of flavonoid curcumin used in cancer treatment are not fully understood. The results of this study suggest that curcumin evidently inhibits epithelial-mesenchymal transition, cell growth, and invasion of hepatocellular carcinoma cell lines HepG2 and Huh-7, as well as the Wnt/β-catenin signal pathway. Curcumin might exert anti-tumor effect on hepatocellular carcinoma cells by regulating the TET1/Wnt/β-catenin signal pathway to inhibit the epithelial-mesenchymal transition progress.

Keywords: TET1/Wnt/β-catenin signal axis; curcumin; epithelial–mesenchymal transition; hepatocellular carcinoma.

MeSH terms

  • Carcinoma, Hepatocellular* / metabolism
  • Cell Line, Tumor
  • Cell Movement
  • Cell Proliferation
  • Curcumin* / pharmacology
  • Epithelial-Mesenchymal Transition
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Liver Neoplasms* / metabolism
  • Mixed Function Oxygenases / metabolism
  • Proto-Oncogene Proteins / metabolism
  • Wnt Signaling Pathway
  • beta Catenin / genetics
  • beta Catenin / metabolism

Substances

  • beta Catenin
  • Curcumin
  • TET1 protein, human
  • Mixed Function Oxygenases
  • Proto-Oncogene Proteins