Lung cancer metastasis to oral soft tissues; Systematic review of 122 cases

Sonia Gupta; Manveen-Kaur Jawanda; Neal-Bharat Kedia; Aayush-Ranjan Deb; Aruna Ganganna; Kumar Saurabh; Sumit-Kumar Yadav; Achla-Bharti Yadav

doi:10.4317/jced.59773

Lung cancer metastasis to oral soft tissues; Systematic review of 122 cases

J Clin Exp Dent. 2022 Oct 1;14(10):e854-e874. doi: 10.4317/jced.59773. eCollection 2022 Oct.

Authors

Sonia Gupta¹, Manveen-Kaur Jawanda², Neal-Bharat Kedia³, Aayush-Ranjan Deb⁴, Aruna Ganganna⁵, Kumar Saurabh⁶, Sumit-Kumar Yadav⁷, Achla-Bharti Yadav⁸

Affiliations

¹ MDS, Reader, Dept. of Oral Pathology and Microbiology & Forensic odontology, Rayat and Bahra Dental college and hospital, Mohali, Punjab, India.
² MDS, Professor & Head, Dept. of Oral Pathology and Microbiology & Forensic odontology. Laxmi bai institute of dental sciences and hospital, Patiala, Punjab, India.
³ MDS, Professor & PG Guide, Dept. of Orthodontics & Dentofacial Orthopedics, Buddha Institute of Dental Sciences & Hospital, Patna, Bihar, India.
⁴ BDS, Intern, Sri Ramachandra Faculty of Dental Sciences, Porur, Chennai, Tamilnadu, India.
⁵ MDS, Assistant Professor, Department of Periodontology, JSS Dental College and Hospital, Mysore, Karnataka, India.
⁶ MDS, Medical Officer (Dental Surgeon), PHC, Bind, Bihar, IndiaMDS, Medical Officer (Dental Surgeon), PHC, Bind, Bihar, India.
⁷ MDS, Professor, Department of Orthodontics & Dentofacial Orthopedics, D J College of Dental Sciences & Research, Modinagar, UP, India.
⁸ MDS, Professor, Department of Oral Pathology & Microbiology, D J College of Dental Sciences and Research, Modinagar, UP, India.

Abstract

Background: Lung cancer metastasis to oral region is very rare. Studies have been published analysing the cases of metastatic tumours to the oral cavity by many researchers. But very few research work has been conducted till date to analyse only the oral soft tissue metastasis from Lung cancer as the primary source. The goal of this study was to examine published cases of oral soft tissue metastasis from lung cancer as the only primary source from 1st August 1977 to 31st December 2021.

Material and methods: An electronic search of the published English literature was performed in PubMed/ Medline, Scopus, Google Scholar, and Research gate databases, using keywords like 'Lung cancer', OR/ AND 'Lung carcinoma' OR/ AND 'Oral cavity', OR/AND 'Metastasis', OR/AND 'Primary', OR/AND 'Source', OR/AND 'Initial', OR/AND 'Tongue', OR/AND 'Palate', OR/ AND 'Tonsil', OR/AND 'Lip', OR/AND 'Buccal mucosa', OR/AND 'Floor of mouth', OR/AND 'Salivary glands', OR/ AND 'Parotid', OR/ AND 'Submandibular', OR/ AND 'Sublingual' OR/ AND 'Mandible', OR/AND 'Maxilla. We also searched all related journals manually. Reference list of all articles was also checked.

Results: Our research revealed total 122 patients. The most prevalent diagnosed metastatic lung cancer was adenocarcinoma. Gingiva, tongue and tonsils were the most common site of metastasis. 54% patients died of metastasis with a survival time of 1 week to 2.5 years.

Conclusions: Oral soft tissue metastasis from lung cancer has a bad prognosis. More cases need to be published in order to raise awareness of these lesions and gain a better understanding of their characteristics. Key words:Lung cancer, metastasis, oral, primary, soft tissues.

Publication types

Review