Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications

Xinyang Zhong; Xuefeng He; Yaxian Wang; Zijuan Hu; Huixia Huang; Senlin Zhao; Ping Wei; Dawei Li

doi:10.1186/s13045-022-01358-5

Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications

J Hematol Oncol. 2022 Nov 1;15(1):160. doi: 10.1186/s13045-022-01358-5.

Authors

Xinyang Zhong^#^{1

2}, Xuefeng He^#^{1

2}, Yaxian Wang^{1

2}, Zijuan Hu^{3

4

5

2}, Huixia Huang^{3

4

5

2}, Senlin Zhao^{1

2}, Ping Wei^{6

7

8

9}, Dawei Li^{10

11}

Affiliations

¹ Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
² Department of Oncology, Shanghai Medical College Fudan University, Shanghai, China.
³ Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
⁴ Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China.
⁵ Institute of Pathology, Fudan University, Shanghai, China.
⁶ Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. weiping@fudan.edu.cn.
⁷ Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China. weiping@fudan.edu.cn.
⁸ Institute of Pathology, Fudan University, Shanghai, China. weiping@fudan.edu.cn.
⁹ Department of Oncology, Shanghai Medical College Fudan University, Shanghai, China. weiping@fudan.edu.cn.
¹⁰ Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. li_dawei@fudan.edu.cn.
¹¹ Department of Oncology, Shanghai Medical College Fudan University, Shanghai, China. li_dawei@fudan.edu.cn.

^# Contributed equally.

Abstract

Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related death worldwide. Countless CRC patients undergo disease progression. As a hallmark of cancer, Warburg effect promotes cancer metastasis and remodels the tumor microenvironment, including promoting angiogenesis, immune suppression, cancer-associated fibroblasts formation and drug resistance. Targeting Warburg metabolism would be a promising method for the treatment of CRC. In this review, we summarize information about the roles of Warburg effect in tumor microenvironment to elucidate the mechanisms governing Warburg effect in CRC and to identify novel targets for therapy.

Keywords: Colorectal cancer; Metastasis; Therapeutics; Tumor microenvironment; Warburg effect.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cancer-Associated Fibroblasts* / pathology
Colorectal Neoplasms* / pathology
Disease Progression
Humans
Tumor Microenvironment

Abstract

Publication types

MeSH terms

Grants and funding