Integrative analyses of genes about venous thromboembolism: An umbrella review of systematic reviews and meta-analyses

Sangyeob Lee; Chang Han Lee; Min Seok Seo; Jun-Il Yoo

doi:10.1097/MD.0000000000031162

Integrative analyses of genes about venous thromboembolism: An umbrella review of systematic reviews and meta-analyses

Medicine (Baltimore). 2022 Oct 28;101(43):e31162. doi: 10.1097/MD.0000000000031162.

Authors

Sangyeob Lee^{1

2}, Chang Han Lee³, Min Seok Seo⁴, Jun-Il Yoo⁴

Affiliations

¹ Department of Biomedical Research Institute, Gyeongsang national university hospital, Jinju, South Korea.
² Department of Theriogenology and Biotechnology, College of Veterinary Medicine, Gyeongsang National University, Jinju, South Korea.
³ Department of Rehabilitation Medicine, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, South Korea.
⁴ Department of Orthopaedic Surgery, Gyeongsang national university hospital, Jinju, South Korea.

Abstract

Background: In recent years, many studies have found possible links between gene polymorphisms and venous thromboembolism (VTE). By identifying genetic risk factors before facing environmental risk factors such as surgical interventions and COVID-19 vaccination, we could rapidly respond to the risk of VTE. The aim of this study was to perform an umbrella review of genetic variants related to VTE. Integrative gene analysis of VTE was performed to identify critical genetic variations.

Methods: This study conducted an umbrella review of systematic reviews and meta-analyses. All included studies were selected from the PubMed/MEDLINE database. To select eligible studies, the following variables were extracted: first author name; effect size of each study genetic variant; year of publication; the number of studies included in each article; ethnicity, sample size, P values, and heterogeneity estimates. To assess cumulative evidence in genetic epidemiology about effects of gene polymorphisms on VTE, Human Genome Epidemiology Network's Venice criteria were used. Methodological quality assessment was conducted with JBI Critical Appraisal Checklist for Systematic Reviews and Research Syntheses.

Results: Genes provided in the present study with genetic variants associated with VTE were FVL (G1691A), Prothrombin (G20210A), MTHFR (C677T, A1298C), PAI-1 (4G/5G), factor VII activating protease (1601G > A), and endothelial protein C receptor (g.6936A_G, c.4600A_G). Among them, variants in FVL, Prothrombin, MTHFR, and PAI-1 showed high significance. Particularly, variants in Prothrombin (G20210A), MTHFR (C677T), and PAI-1 (4G/5G) had more than 2 types of model significance.

Conclusion: The present study performed a systematic review of genetic variants associated with VTE. Our results could lead to a more comprehensive understanding of VTE etiology. These results could give a strategy of prediagnosis about evaluating individual risks of VTE who might be exposed to environmental risk factors.

Publication types

Review

MeSH terms

COVID-19 Vaccines
COVID-19*
Humans
Meta-Analysis as Topic
Methylenetetrahydrofolate Reductase (NADPH2) / genetics
Plasminogen Activator Inhibitor 1 / genetics
Prothrombin / genetics
Systematic Reviews as Topic
Venous Thromboembolism* / epidemiology
Venous Thromboembolism* / genetics

Substances

COVID-19 Vaccines
Methylenetetrahydrofolate Reductase (NADPH2)
Plasminogen Activator Inhibitor 1
Prothrombin