Association of haemoglobin glycation index with outcomes in patients with acute coronary syndrome: results from an observational cohort study in China

Jiayu Li; Yanguo Xin; Jingye Li; Li Zhou; Hui Qiu; Aidong Shen; Hui Chen; Hongwei Li

doi:10.1186/s13098-022-00926-6

Association of haemoglobin glycation index with outcomes in patients with acute coronary syndrome: results from an observational cohort study in China

Diabetol Metab Syndr. 2022 Oct 31;14(1):162. doi: 10.1186/s13098-022-00926-6.

Authors

Jiayu Li^#¹, Yanguo Xin^#¹, Jingye Li¹, Li Zhou¹, Hui Qiu¹, Aidong Shen¹, Hui Chen², Hongwei Li^{3

4

5}

Affiliations

¹ Department of Cardiology, Beijing Friendship Hospital, Capital Medical University. No, 95 Yong'an Road, Xicheng District, Beijing, 100050, China.
² Department of Cardiology, Beijing Friendship Hospital, Capital Medical University. No, 95 Yong'an Road, Xicheng District, Beijing, 100050, China. 13910710028@163.com.
³ Department of Cardiology, Beijing Friendship Hospital, Capital Medical University. No, 95 Yong'an Road, Xicheng District, Beijing, 100050, China. lhw19656@sina.com.
⁴ Department of Internal Medical, Medical Health Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China. lhw19656@sina.com.
⁵ Beijing Key Laboratory of Metabolic Disorder Related Cardiovascular Disease, Beijing, China. lhw19656@sina.com.

^# Contributed equally.

Abstract

Background: The hemoglobin glycation index (HGI) is the difference between measured and estimated glycation of hemoglobin. However, there is limited evidence to investigate the HGI and the clinical outcomes of acute coronary syndrome patients. This study aimed to evaluate the association between HGI and the clinical outcomes of acute coronary syndrome (ACS) in a China cohort.

Method: This single-center retrospective study was carried out in the Cardiovascular Center of Beijing Friendship Hospital, a total of 11004 consecutive patients with ACS from Dec 2012-Dec 2020 were enrolled in this study. Patients were divided into quintiles according to their HGI levels. The incidence of major adverse cardiac and cerebrovascular events (MACCEs) was recorded.

Result: HGI were divided into five quintiles quintiles: -0.906 (-7.188, -0.663), -0.491 (-0.663, -0.343), -0.196 (-0.342, -0.039), 0.170 (-0.039, 0.485), and 1.156 (0.485, 7.875), respectively. Competing risk regression revealed that HGI was positively related to all-cause death, CV death, and composite MACCEs. Multivariate Cox proportional hazards regression analysis indicated that hypertension (HR:1.109, P = 0.013), previous stroke (HR:1.208, P < 0.001), past PCI (HR: 1.268, P < 0.001), age (HR: 1.011, P < 0.001), BMI (HR: 0.987, P = 0.012), heart rate (HR: 1.004, P = 0.001), NSTEMI (HR: 1.205, P < 0.001), WBC (HR: 1.020, P = 0.008), eGFR (HR: 0.993, P < 0.001), HDL-C (HR: 0.809, P = 0.002), LVEF (HR:0.240, P < 0.001), LM/three-vessel or proximal LAD involved (HR: 1.208 P < 0.001; HR:0.914, P = 0.019, respectively), and antiplatelet agents during hospitalization (HR:0.806, P = 0.020) independently predicted the incidence of MACCEs in ACS patients. Restricted cubic spline indicated a U-shaped association between the HGI and risk of MACCEs.

Conclusion: Both low HGI and high HGI was associated with an increased risk of adverse outcomes in patients with acute coronary syndrome, compared with moderate HGI.

Keywords: Acute coronary syndrome; China; Hemoglobin glycation index; Major adverse cardiac and cerebrovascular events.

Abstract

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