Chrysin: A polyedric flavone as a tool to explore new phytotherapeutic applications and drug design

Arch Pharm (Weinheim). 2023 Feb;356(2):e2200347. doi: 10.1002/ardp.202200347. Epub 2022 Oct 31.

Abstract

In the field of pharmaceutical research, a branch that has become more and more interesting is phytochemistry. Among phytochemicals, flavonoids have been studied a lot over the past 30 years. This review summarizes the chemical characteristics, metabolism, applications, and toxicity of a particular flavonoid, chrysin, recorded in the last 10 years and supported by solid biological assays. Furthermore, this review highlights some derivatives of chrysin investigated to obtain more bioavailable molecules that maintain or improve chrysin's bioactivities, enclosing a chrysin patent section, as well.

Keywords: anti-inflammatory activity; anticancer activity; antidiabetic activity; cardio protection; chrysin.

Publication types

  • Review

MeSH terms

  • Drug Design
  • Flavones* / pharmacology
  • Flavonoids* / chemistry
  • Flavonoids* / pharmacology
  • Structure-Activity Relationship

Substances

  • chrysin
  • Flavonoids
  • Flavones