Predictive value of DCE-MRI and IVIM-DWI in osteosarcoma patients with neoadjuvant chemotherapy

Xibin Xia; Lu Wen; Feng Zhou; Junjun Li; Qiang Lu; Jun Liu; Xiaoping Yu

doi:10.3389/fonc.2022.967450

Predictive value of DCE-MRI and IVIM-DWI in osteosarcoma patients with neoadjuvant chemotherapy

Front Oncol. 2022 Oct 14:12:967450. doi: 10.3389/fonc.2022.967450. eCollection 2022.

Authors

Xibin Xia¹, Lu Wen¹, Feng Zhou², Junjun Li³, Qiang Lu¹, Jun Liu¹, Xiaoping Yu¹

Affiliations

¹ Department of Diagnostic Radiology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.
² Department of Orthopedics and Soft Tissue, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.
³ Department of Pathology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.

Abstract

Objective: To investigate the predictive value of dynamic contrast enhanced MRI (DCE-MRI) and intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) for clinical outcomes of osteosarcoma patients with neoadjuvant chemotherapy.

Methods: The present prospective single-arm cohort study enrolled 163 patients of osteosarcoma during July 2017 to July 2022. All patients received the same treatment strategy of neoadjuvant chemotherapy. Both DCE-MRI and IVIM-DWI were conducted for the patients before the chemotherapy, as well as after one or two chemotherapy treatment cycles. The imaging parameters of contrast agent transfer rate between blood and tissue (K^trans ), contrast agent back-flux rate constant (K_ep ), extravascular extracellular fractional volume (V_e ), as well as pure diffusion coefficient (D value), pseudo-diffusion coefficient (D* value), apparent diffusion coefficient (ADC) and the perfusion fraction (f value) were recorded. RECIST standard [complete response (CR), partial response (PR), stable disease (SD), progressive disease (PD)] was used as the main clinical outcome.

Results: After two treatment cycles, 112 (68.71%) cases were with CR and PR, 31 (19.02%) cases were with SD and 20 cases (12.27%) were with PD. After 1~2 treatment cycles, patients with CR/PR showed significantly markedly lower K^trans , K_ep , V_e values, while higher D, ADC and f values compared with SD or PD patients. Alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) were positively correlated with values of K^trans , K_ep , and V_e , while negative correlation was observed between ALP and values of D, ADC and f, as well as between LDH and D and ADC after the whole treatment. D and K_ep values after two treatment cycles showed the best predictive value for diagnosis of PD. The values of K^tran , K_ep , ADC as well as ALP and LDH were all risk factors for PD after neoadjuvant chemotherapy.

Conclusion: DCE-MRI and IVIM-DWI have the potential to predict clinical outcomes of osteosarcoma patients with neoadjuvant chemotherapy.

Keywords: DCE-MRI; IVIM-DWI; clinical outcomes; osteosarcoma; predictor.