Exosomes and mimics as novel delivery platform for cancer therapy

Fuxu Yang; Mingyue Wang; Xingang Guan

doi:10.3389/fphar.2022.1001417

Exosomes and mimics as novel delivery platform for cancer therapy

Front Pharmacol. 2022 Oct 12:13:1001417. doi: 10.3389/fphar.2022.1001417. eCollection 2022.

Authors

Fuxu Yang^{1

2}, Mingyue Wang^{2

3}, Xingang Guan¹

Affiliations

¹ Department of Basic Medicine, School of Medicine, Taizhou University, Taizhou, China.
² Key Laboratory of Pharmaceutics and Bioengineering, School of Medical Technology, Beihua University, Jilin, China.
³ Center of Reproductive Medicine and Center of Prenatal Diagnosis, First Hospital, Jilin University, Changchun, China.

Abstract

Exosomes are nano-sized biological extracellular vesicles transmitting information between cells and constituting a new intercellular communication mode. Exosomes have many advantages as an ideal drug delivery nanocarrier, including good biocompatibility, permeability, low toxicity, and low immunogenicity. Recently, exosomes have been used to deliver chemotherapeutic agents, natural drugs, nucleic acid drugs, and other antitumor drugs to treat many types of tumors. Due to the limited production of exosomes, synthetic exosome-mimics have been developed as an ideal platform for drug delivery. This review summarizes recent advances in the application of exosomes and exosome-mimics delivering therapeutic drugs in treating cancers.

Keywords: cancer therapy; drug delivery; exosome; nanovesicle; tumor targeting.

Publication types

Review