Functional brain changes using electroencephalography after a 24-week multidomain intervention program to prevent dementia

Hee Kyung Park; Seong Hye Choi; SeonMyeong Kim; Ukeob Park; Seung Wan Kang; Jee Hyang Jeong; So Young Moon; Chang Hyung Hong; Hong-Sun Song; Buong-O Chun; Sun Min Lee; Muncheong Choi; Kyung Won Park; Byeong C Kim; Soo Hyun Cho; Hae Ri Na; Yoo Kyoung Park

doi:10.3389/fnagi.2022.892590

Functional brain changes using electroencephalography after a 24-week multidomain intervention program to prevent dementia

Front Aging Neurosci. 2022 Oct 12:14:892590. doi: 10.3389/fnagi.2022.892590. eCollection 2022.

Authors

Hee Kyung Park^{1

2}, Seong Hye Choi³, SeonMyeong Kim⁴, Ukeob Park⁴, Seung Wan Kang^{4

5}, Jee Hyang Jeong¹, So Young Moon⁶, Chang Hyung Hong⁷, Hong-Sun Song⁸, Buong-O Chun⁹, Sun Min Lee⁶, Muncheong Choi¹⁰, Kyung Won Park¹¹, Byeong C Kim¹², Soo Hyun Cho¹², Hae Ri Na¹³, Yoo Kyoung Park^{14

15}

Affiliations

¹ Department of Neurology, Ewha Womans University School of Medicine, Seoul, South Korea.
² Department of Mental Health Care of Older People, Division of Psychiatry, University College London, London, United Kingdom.
³ Department of Neurology, Inha University School of Medicine, Incheon, South Korea.
⁴ iMediSync Inc., Seoul, South Korea.
⁵ Data Center for Korean EEG, College of Nursing, Seoul National University, Seoul, South Korea.
⁶ Department of Neurology, Ajou University School of Medicine, Suwon, South Korea.
⁷ Department of Psychiatry, Ajou University School of Medicine, Suwon, South Korea.
⁸ Department of Sports Sciences, Korea Institute of Sports Science, Seoul, South Korea.
⁹ Graduate School of Physical Education, College of Arts and Physical Education, Myongji University, Seoul, South Korea.
¹⁰ Department of Sports and Health Science, Shinhan University, Uijeongbu-si, South Korea.
¹¹ Department of Neurology, Dong-A University College of Medicine, Busan, South Korea.
¹² Department of Neurology, Chonnam National University Medical School and Hospital, Gwangju, South Korea.
¹³ Department of Neurology, Bobath Memorial Hospital, Seongnam, South Korea.
¹⁴ Department of Medical Nutrition, Graduate School of East-West Medical Nutrition, Kyung Hee University, Yongin, South Korea.
¹⁵ Department of Food Innovation and Health, Graduate School of East-West Medical Nutrition, Kyung Hee University, Yongin, South Korea.

Abstract

Quantitative electroencephalography (QEEG) has proven useful in predicting the response to various treatments, but, until now, no study has investigated changes in functional connectivity using QEEG following a lifestyle intervention program. We aimed to investigate neurophysiological changes in QEEG after a 24-week multidomain lifestyle intervention program in the SoUth Korean study to PrEvent cognitive impaiRment and protect BRAIN health through lifestyle intervention in at-risk elderly people (SUPERBRAIN). Participants without dementia and with at least one modifiable dementia risk factor, aged 60-79 years, were randomly assigned to the facility-based multidomain intervention (FMI) (n = 51), the home-based multidomain intervention (HMI) (n = 51), and the control group (n = 50). The analysis of this study included data from 44, 49, and 34 participants who underwent EEG at baseline and at the end of the study in the FMI, HMI, and control groups, respectively. The spectrum power and power ratio of EEG were calculated. Source cortical current density and functional connectivity were estimated by standardized low-resolution brain electromagnetic tomography. Participants who received the intervention showed increases in the power of the beta1 and beta3 bands and in the imaginary part of coherence of the alpha1 band compared to the control group. Decreases in the characteristic path lengths of the alpha1 band in the right supramarginal gyrus and right rostral middle frontal cortex were observed in those who received the intervention. This study showed positive biological changes, including increased functional connectivity and higher global efficiency in QEEG after a multidomain lifestyle intervention.

Clinical trial registration: [https://clinicaltrials.gov/ct2/show/NCT03980392] identifier [NCT03980392].

Keywords: biomarkers; cognitive impairment; dementia; multidomain intervention; quantitative electroencephalography.

Associated data

ClinicalTrials.gov/NCT03980392