The cumulative effect of chronic stress and depressive symptoms affects heart rate in a working population

Erika Lutin; Carmen Schiweck; Jan Cornelis; Walter De Raedt; Andreas Reif; Elske Vrieze; Stephan Claes; Chris Van Hoof

doi:10.3389/fpsyt.2022.1022298

The cumulative effect of chronic stress and depressive symptoms affects heart rate in a working population

Front Psychiatry. 2022 Oct 13:13:1022298. doi: 10.3389/fpsyt.2022.1022298. eCollection 2022.

Authors

Erika Lutin^{1

2}, Carmen Schiweck³, Jan Cornelis², Walter De Raedt², Andreas Reif³, Elske Vrieze^{4

5}, Stephan Claes^{4

5}, Chris Van Hoof^{1

2

6}

Affiliations

¹ Electrical Engineering-ESAT, KU Leuven, Leuven, Belgium.
² Imec, Leuven, Belgium.
³ Department of Psychiatry, Psychosomatics and Psychotherapy, Goethe University, Frankfurt am Main, Germany.
⁴ Department of Neurosciences, Psychiatry Research Group, KU Leuven, Leuven, Belgium.
⁵ University Psychiatric Centre KU Leuven, Leuven, Belgium.
⁶ OnePlanet Research Center, Wageningen, Netherlands.

Abstract

Background: Chronic stress and depressive symptoms have both been linked to increased heart rate (HR) and reduced HR variability. However, up to date, it is not clear whether chronic stress, the mechanisms intrinsic to depression or a combination of both cause these alterations. Subclinical cases may help to answer these questions. In a healthy working population, we aimed to investigate whether the effect of chronic stress on HR circadian rhythm depends on the presence of depressive symptoms and whether chronic stress and depressive symptoms have differential effects on HR reactivity to an acute stressor.

Methods: 1,002 individuals of the SWEET study completed baseline questionnaires, including psychological information, and 5 days of electrocardiogram (ECG) measurements. Complete datasets were available for 516 individuals. In addition, a subset (n = 194) of these participants completed a stress task on a mobile device. Participants were grouped according to their scores for the Depression Anxiety Stress Scale (DASS) and Perceived Stress Scale (PSS). We explored the resulting groups for differences in HR circadian rhythm and stress reactivity using linear mixed effect models. Additionally, we explored the effect of stress and depressive symptoms on night-time HR variability [root mean square of successive differences (RMSSD)].

Results: High and extreme stress alone did not alter HR circadian rhythm, apart from a limited increase in basal HR. Yet, if depressive symptoms were present, extreme chronic stress levels did lead to a blunted circadian rhythm and a lower basal HR. Furthermore, blunted stress reactivity was associated with depressive symptoms, but not chronic stress. Night-time RMSSD data was not influenced by chronic stress, depressive symptoms or their interaction.

Conclusion: The combination of stress and depressive symptoms, but not chronic stress by itself leads to a blunted HR circadian rhythm. Furthermore, blunted HR reactivity is associated with depressive symptoms and not chronic stress.

Keywords: chronic stress; circadian rhythm; depressive symptoms; heart rate; stress reactivity.