Plant-derived nanovesicles: Current understanding and applications for cancer therapy

Ngoc Phung Ly; Hwa Seung Han; Myungsuk Kim; Jae Hyung Park; Ki Young Choi

doi:10.1016/j.bioactmat.2022.10.005

Plant-derived nanovesicles: Current understanding and applications for cancer therapy

Bioact Mater. 2022 Oct 20:22:365-383. doi: 10.1016/j.bioactmat.2022.10.005. eCollection 2023 Apr.

Authors

Ngoc Phung Ly^{1

2}, Hwa Seung Han¹, Myungsuk Kim¹, Jae Hyung Park^{3

4

5}, Ki Young Choi^{1

2}

Affiliations

¹ Natural Product Informatics Research Center, Korea Institute of Science and Technology (KIST), Gangneung, 25451, Republic of Korea.
² Division of Bio-Medical Science and Technology, KIST School, University of Science and Technology (UST), Seoul, 02792, Republic of Korea.
³ School of Chemical Engineering, College of Engineering, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
⁴ Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, 06351, Republic of Korea.
⁵ Biomedical Institute for Convergence at SKKU, Sungkyunkwan University, Suwon, 16419, Republic of Korea.

Abstract

Plant-derived vesicles (PDVs) are membranous structures that originate from plant cells and are responsible for multiple physiological and pathological functions. In the last decade, PDVs have gained much attention for their involvement in different biological processes, including intercellular communication and defense response, and recent scientific evidence has opened a new avenue for their applications in cancer treatment. Nevertheless, much remains unknown about these vesicles, and current research remains inconsistent. This review aims to provide a comprehensive introduction to PDVs, from their biological characteristics to purification methods, and to summarize the status of their potential development for cancer therapy.

Keywords: Anti-cancer; Cancer therapy; Drug delivery; Extracellular vesicles; Plant-derived vesicles.