Molecular regulation after mucosal injury and regeneration in ulcerative colitis

Lie Zheng; Sheng-Lei Duan; Xin-Li Wen; Yan-Cheng Dai

doi:10.3389/fmolb.2022.996057

Molecular regulation after mucosal injury and regeneration in ulcerative colitis

Front Mol Biosci. 2022 Oct 13:9:996057. doi: 10.3389/fmolb.2022.996057. eCollection 2022.

Authors

Lie Zheng¹, Sheng-Lei Duan¹, Xin-Li Wen¹, Yan-Cheng Dai²

Affiliations

¹ Department of Gastroenterology, Shaanxi Hospital of Traditional Chinese Medicine, Xi'an, Shaanxi Province, China.
² Department of Gastroenterology, Shanghai Traditional Chinese Medicine Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Abstract

Ulcerative colitis (UC) is a chronic nonspecific inflammatory disease with a complex etiology. Intestinal mucosal injury is an important pathological change in individuals with UC. Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5+) intestinal stem cells (ISCs) exhibit self-renewal and high differentiation potential and play important roles in the repair of intestinal mucosal injury. Moreover, LGR5+ ISCs are intricately regulated by both the Wnt/β-catenin and Notch signaling pathways, which jointly maintain the function of LGR5+ ISCs. Combination therapy targeting multiple signaling pathways and transplantation of LGR5+ ISCs may lead to the development of new clinical therapies for UC.

Keywords: intestinal stem cells; molecular regulation; mucosal injury; regeneration; ulcerative colitis.

Publication types

Review