The raging global epidemic of coronavirus disease 2019 (COVID-19) not only poses a major threat to public health, but also has a huge impact on the global health care system and social and economic development. Therefore, accelerating the development of vaccines and antibody drugs to provide people with effective protection and treatment measures has become the top priority of researchers and medical institutions in the field. At present, several vaccines and antibody drugs targeting SARS-Cov-2 have been in the stage of clinical research or approved for marketing around the world. In this manuscript, we summarized the vaccines and antibody drugs which apply genetic engineering technologies to target spike protein, including subunit vaccines, viral vector vaccines, DNA vaccines, mRNA vaccines, and several neutralizing antibody drugs, and discussed the trends of vaccines and antibody drugs in the future.
新型冠状病毒肺炎（COVID-19）疫情在全球的肆虐，不仅对公众的健康造成了重大威胁，也对全球卫生医疗系统和社会经济发展带来了巨大冲击。因此，加快疫苗和抗体药物的研发，为人们提供有效的保护和治疗措施，成为广大科学研究人员和医疗机构的首要任务。目前全球已有多款新冠疫苗和抗体药物进入临床研究或获批上市，本文对多款利用基因工程技术研发的基于S蛋白的新冠疫苗和抗体（包括亚单位疫苗、病毒载体疫苗、DNA疫苗、mRNA疫苗以及一些中和抗体药物）进行了简要阐述，同时也对疫苗和抗体药物的未来发展进行了探讨。.
Keywords: Antibody; Genetic engineering; SARS-CoV-2; Spike; Vaccine.