Racemic norneolignans from the resin of Ferula sinkiangensis and their COX-2 inhibitory activity

Xing-Hui Bao; Yan-Peng Li; Qian Li; Yong-Xian Cheng; Ya-Bing Jiao; Hao-Xing Zhang; Yong-Ming Yan

doi:10.1016/j.fitote.2022.105341

Racemic norneolignans from the resin of Ferula sinkiangensis and their COX-2 inhibitory activity

Fitoterapia. 2023 Jan:164:105341. doi: 10.1016/j.fitote.2022.105341. Epub 2022 Oct 27.

Authors

Xing-Hui Bao¹, Yan-Peng Li¹, Qian Li¹, Yong-Xian Cheng¹, Ya-Bing Jiao¹, Hao-Xing Zhang², Yong-Ming Yan³

Affiliations

¹ Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmaceutical Sciences, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, PR China.
² Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmaceutical Sciences, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, PR China. Electronic address: zhang.haoxing@szu.edu.cn.
³ Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmaceutical Sciences, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, PR China. Electronic address: yanym@szu.edu.cn.

PMID: 36309142
DOI: 10.1016/j.fitote.2022.105341

Abstract

Five new norneolignans sinkianlignans G-K (1-5), one phenolic compound ferulagenol A (6) and seven known compounds (7-13) were isolated from Ferula sinkiangensis. All the norneolignans were racemic mixtures, and chiral HPLC was used to further separate them. Their structures were assigned, including absolute configurations, using spectroscopic and computational methods. Biological evaluation showed that compounds 1-9 had significant COX-2 inhibitory activity with IC₅₀ values ranging from 3.00 μM to 23.19 μM.

Keywords: COX-2; Ferula sinkiangensis; Norneolignans; Racemic; Resin.

MeSH terms

Cyclooxygenase 2
Cyclooxygenase 2 Inhibitors* / pharmacology
Ferula* / chemistry
Molecular Structure

Substances

Cyclooxygenase 2 Inhibitors
Cyclooxygenase 2