A combination of exercise and calorie restriction improves the development of obesity-related type 2 diabetes mellitus in KKAy mice

Biosci Biotechnol Biochem. 2022 Dec 21;87(1):108-113. doi: 10.1093/bbb/zbac170.

Abstract

We observed that exercise and calorie restriction reduced the body weight and blood glucose levels, concurrently improving insulin resistance and glucose tolerance in obese/diabetic model KKAy mice. Analysis of gene expression in the skeletal muscle showed enhanced mRNA levels of GLUT4 (glucose uptake), ATGL (lipolytic enzyme), and slow-twitch myosin heavy chain, which may contribute to the antiobesity and antidiabetic effects.

Keywords: calorie restriction; exercise; glucose tolerance; obesity; type 2 diabetes mellitus.

MeSH terms

  • Animals
  • Blood Glucose / metabolism
  • Caloric Restriction
  • Diabetes Mellitus, Type 2*
  • Glucose Transporter Type 4 / genetics
  • Glucose Transporter Type 4 / metabolism
  • Hypoglycemic Agents / pharmacology
  • Insulin
  • Insulin Resistance* / physiology
  • Mice
  • Muscle, Skeletal / metabolism
  • Obesity / complications
  • Obesity / metabolism
  • Obesity / therapy

Substances

  • Hypoglycemic Agents
  • Blood Glucose
  • Insulin
  • Glucose Transporter Type 4