Targeting the biological activity and biosynthesis of hyperforin: a mini-review

Shuqin Liu; Beilei Yu; Jungui Dai; Ridao Chen

doi:10.1016/S1875-5364(22)60189-4

Targeting the biological activity and biosynthesis of hyperforin: a mini-review

Chin J Nat Med. 2022 Oct;20(10):721-728. doi: 10.1016/S1875-5364(22)60189-4.

Authors

Shuqin Liu¹, Beilei Yu¹, Jungui Dai¹, Ridao Chen²

Affiliations

¹ State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
² State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address: chenridao@imm.ac.cn.

PMID: 36307194
DOI: 10.1016/S1875-5364(22)60189-4

Abstract

Hyperforin is a representative polycyclic polyprenylated acylphloroglucinols (PPAPs) that exerts a variety of pharmacological activities. The complete biosynthesis pathway of hyperforin has not been elucidated due to its complex structure and unclear genetic background of its source plants. This mini-review focuses on the bioactivity and biosynthesis of hyperforin. These analyses can provide useful insights into the biosynthesis investigations of hyperforin and other PPAPs with complex structures.

Keywords: Bioactivity; Biosynthesis; Hyperforin; PPAPs; Prenyltransferase.

Publication types

Review

MeSH terms

Hypericum* / chemistry
Molecular Structure
Phloroglucinol* / chemistry
Phloroglucinol* / pharmacology
Terpenes / chemistry
Terpenes / pharmacology

Substances

hyperforin
Phloroglucinol
Terpenes