Microglia are SYK of Aβ and cell debris

Dorothy P Schafer; Jacob M Stillman

doi:10.1016/j.cell.2022.09.043

Microglia are SYK of Aβ and cell debris

Cell. 2022 Oct 27;185(22):4043-4045. doi: 10.1016/j.cell.2022.09.043.

Authors

Dorothy P Schafer¹, Jacob M Stillman²

Affiliations

¹ Department of Neurobiology, Brudnik Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA. Electronic address: dorothy.schafer@umassmed.edu.
² Department of Neurobiology, Brudnik Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA; University of Massachusetts Chan Morningside Graduate School of Biomedical Sciences, Neuroscience Program, Worcester, MA, USA.

PMID: 36306731
DOI: 10.1016/j.cell.2022.09.043

Abstract

During neurodegenerative disease, resident CNS macrophages termed "microglia" assume a neuroprotective role and engulf toxic protein aggregates and cell debris. In this issue of Cell, two groups independently show how spleen tyrosine kinase (SYK) acts downstream of microglial surface receptors to propagate this neuroprotective program in vivo.

Publication types

Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Comment

MeSH terms

Humans
Macrophages
Microglia* / metabolism
Neurodegenerative Diseases* / metabolism
Syk Kinase / metabolism

Substances

SYK protein, human
Syk Kinase

Abstract

Publication types

MeSH terms

Substances

Grants and funding